Scientist, Medicinal Chemistry, Discovery

POINT Biopharma Global Inc. is a globally focused radiopharmaceutical company building a platform for the clinical development and commercialization of radioligands that fight cancer. POINT aims to transform precision oncology by combining a portfolio of targeted radioligand assets, a seasoned management team, an industry-leading pipeline, in-house manufacturing capabilities, and secured supply for medical isotopes including actinium-225 and lutetium-177. POINT’s active clinical trials include FRONTIER, a phase 1 trial for PNT2004, a pan-cancer program targeting fibroblast activation protein-α (FAP-α), and SPLASH, the phase 3 trial for PNT2002 for people with metastatic castration resistant prostate cancer (mCRPC) after second-line hormonal treatment.

TO BE CONSIDERED, APPLICANTS MUST BE LEGALLY ENTITLED TO WORK IN CANADA.

Location of work

The work location is downtown Toronto near University Avenue and College Street.

Overview

Reporting to the Scientist, Medicinal Chemistry. the Scientist of Medicinal Chemistry will join our Discovery Research team to develop and advance new ligands for targeted radiopharmaceuticals. Research will be primarily focused on drug development of radioligand therapies in oncology. This position will fill an onsite laboratory role in Toronto, Ontario.

Accountabilities

• Support discovery and hit-to-lead efforts for candidate radioligands.
• Design and execute multistep synthesis, purification, and characterization of oligopeptides and small molecules.
• Troubleshoot reactions and propose alternative synthetic scheme or reaction conditions when needed.
• Maintain a command of current scientific literature relevant for ligand development and synthesis.
• Assume leadership responsibilities managing on-site laboratory operations.
• Maintain laboratory notebooks, draft research reports, and present project status updates.
• Collaborate and support CMC and Preclinical operations.
• Work both independently and collaboratively in a multidisciplinary environment.
• Help manage internal scientific databases.
• Maintain a safe working environment through full compliance with health and safety protocols.

Requirements

• PhD in synthetic, medicinal, or organic chemistry or equivalent fields with one to three years of industry or postdoctoral experience.

• Experience with small-molecule synthesis and solid/solution phase peptide synthesis.
• Demonstrated track record of managing scientific projects and leading interdisciplinary teams.
• Ability to perform chemical reactions on a mg to g scale.
• Experience with normal and reverse phase preparatory chromatography.
• Hands-on experience using analytical methods to validate synthesis (HPLC, LC/MS, NMR, etc.)
• Strong understanding of protein-ligand interactions, ADME, physiochemical properties, and principles of medicinal chemistry.
• Experience with Microsoft Word, Excel, PowerPoint, Chemdraw, and MestreNova,
• Exceptional communication skills with the ability to clearly communicate chemistry strategies and reports.
• Experience with ICP-MS is beneficial, but not required.
• This role may require working in collaboration with a hospital setting occasionally, and it is mandatory for all employees to complete health screens before onboarding. In the event the screen results show non-immunity, vaccines may need to be administered.

Why joining POINT today will be the right career move for you:

There is no shortage of demand for smart, qualified and hardworking people like yourself – and we strongly believe POINT is the right career move for you. Here is why:

• You will help establish and define an organization that will change the course of cancer therapies. and help thousands of people each year
• You will be challenged, and are expected to challenge us, as part of a results-oriented, high performance team, where everyone leaves their egos at the door and lets the best ideas win
• You will be provided the opportunity to participate in the financial value creation that occurs as POINT grows and becomes a mature pharmaceutical company
• Most importantly, you will spend everyday working on something important

If what we are saying resonates with you, please submit a resume.

Benefits

• Eligible for annual incentive bonus plan and stock options
• Healthcare plan (medical, dental, vision) – effective day 1
• Disability
• Life insurance
• RRSP matching plan
• Paid Time Off (Vacation, Personal Days, Sick Days & Public Holidays)
• $500 fitness reimbursement
• $50 cell phone reimbursement per pay check ($1,300 per year)

All applicants who are offered employment with POINT Biopharma will be subject to a background investigation. Offers of employment are contingent on the successful completion of a background investigation conducted in accordance with POINT Biopharma policy and state law.

POINT Biopharma does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

We do not accept unsolicited inquiries or resumes from agencies.